Measurement of glomerular filtration rate using a reference method

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How Measuring Glomerular Filtration Rate? Comparison of Reference Methods

Glomerular filtration rate (GFR) is considered as the best way to assess global renal function (Gaspari et al., 1997; Stevens & Levey, 2009). Even if GFR estimations (based on creatinineor cystatin C-based equations) are most often used (see Table 1)(Cockcroft & Gault, 1976; Levey et al., 1999; Levey et al., 2006; Levey et al., 2009), measuring “true” GFR is still important in clinical practice...

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Reference values for glomerular filtration rate in healthy Brazilian adults

BACKGROUND Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS In this cross-sectional study, GFR was measured by the 51Cr-EDTA single-injection method. GFR reference val...

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A High-throughput method for measurement of glomerular filtration rate in conscious mice.

The measurement of glomerular filtration rate (GFR) is the gold standard in kidney function assessment. Currently, investigators determine GFR by measuring the level of the endogenous biomarker creatinine or exogenously applied radioactive labeled inulin ((3)H or (14)C). Creatinine has the substantial drawback that proximal tubular secretion accounts for ~50% of total renal creatinine excretion...

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ژورنال

عنوان ژورنال: Annales de Biologie Clinique

سال: 2019

ISSN: 0003-3898

DOI: 10.1684/abc.2019.1455